When WLAN is open (no encryption and/or authentication), with or without mu to mu communications enabled/disabled, your WLAN is at risk of viruses or malicious attacks.
If you use a open network, every one can connect and sniff data (without connecting to the network!). Disabling MU to MU traffic you can stop attacks like MitM. But honeypots as example are possible.
If you use WPA1/2 with PSK it's the same for all people how know the PSK.
To secure your users you need to use authentication. I recommend to use TLS, it's the most secure connection, but you need a PKI and Certificates for every client. Additional you can use PEAP MSCHAPv2, but it need 1-2 settings to really secure it (verify the AAA server). This can be a problem in a BYOD world.
Without authentication you can't call you network secure. Disabling MU to MU communication just stops communication between mobile units connected to the same wireless SSID.