Hi Thomas,
If you stay on a patch level upgrade (15.3.1p1-10 to 15.3.1p1-41), you should be able to upgrade one stack member at a time. That's not ISSU, but more like Rolling Upgrade. Put the image on one member, reboot it. When it's back and operational, do the same for the other. So really, slot by slot (each command should offer you the slot option).